Itching and Atopy Relief using Azulene Derivatives and High-Content Ceramide Skin Barrier Nano-Liposome Structures by Dry Skin



Clinical study, Itching relief, Guaiazulene, Ceramide, Cosmetics


Atopic dermatitis (AD), a chronic inflammatory skin disease, has increased in industrialized nations, impacting approximately 15 to 20% of children and 1 to 3% of adults worldwide. Previous studies suggest that the impairment of the skin barrier and immunological dysfunction can be considered as the two main factors involved in AD. In this study, a balm formulation containing 0.02% guaiazulene, an azulene derivative, and 1.0% high-content ceramide skin barrier nano-liposome structure was developed to effectively treat AD by normalizing these main factors, and clinical trials were conducted with 23 subjects. Compared to before using the product, (1) the skin moisture content in the forearm area increased significantly (p<0.05) by 25.20% and 63.61% after 2 weeks and 4 weeks of use of the product, respectively, (2) the amount of skin moisture loss in the forearm area decreased significantly (p<0.05) by 12.04% and 17.79% after using the product for 2 weeks and 4 weeks, respectively, (3) the skin texture (roughness) of the forearm area significantly decreased (p<0.05) by 3.00% and 4.18% after 2 weeks and 4 weeks of use, respectively, (4) the degree of itchiness due to dry skin significantly decreased (p<0.05) by 47.91% after 2 weeks of use and 69.71% after 4 weeks of use, and the degree of sleep disturbance due to itching caused by dry skin significantly decreased (p<0.05) by 46.22% after using the product for 2 weeks and by 74.07% after using the product for 4 weeks. This study confirmed the outstanding clinical effects of the formulation containing guaiazulene and ceramide on itching relief caused by dry skin.


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Change of skin moisture content after using the test formulation (n= 23). p 0.05 versus before application




How to Cite

S. I. . Park, K. W. . Lee, S. . Park, and M. S. . Shin, “Itching and Atopy Relief using Azulene Derivatives and High-Content Ceramide Skin Barrier Nano-Liposome Structures by Dry Skin”, Int J Intell Syst Appl Eng, vol. 10, no. 1s, pp. 151 –, Oct. 2022.