Cad System for the Detection and Classification of Alzheimers From Mr Images Using Deep Learning Techniques

Authors

  • Nithya V. P. Research Scholar, Department of Computer Science and Engineering, Karpagam Academy of Higher Education,Coimbatore, Tamil Nadu, India
  • N. Mohanasundaram Professor, Department of Computer Science and Engineering,Faculty 0f Engineering, Karpagam Academy of Higher Education, Coimbatore,Tamil Nadu, India
  • R. Santhosh Professor, Department of Computer Science and Engineering,Faculty 0f Engineering, Karpagam Academy of Higher Education, Coimbatore,Tamil Nadu, India

Keywords:

CLAHE, BADF, K-means clustering, ResNet 50

Abstract

Alzheimer's disease, also known as Alzheimer's degeneration, is an irreversible brain disorder affecting over 65-year-olds.AD cannot currently be cured, but its progression can be slowed by certain treatments.It is imperative to diagnose AD accurately and early to improve patient care and future treatment options.Many ways evaluate picture features to retrieve handmade characteristics and then design a classifier to differentiate AD from other groups. The Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset is used to propose a new method for categorizing AD and MCI.Preprocessing of brain pictures, including image segmentation, is essential for these methods.To reduce noise and factor fluctuations, the pictures are preprocessed using several complex methods.The preprocessed images are then used to segment the images.This study presents a novel classification algorithm based on deep learning and ResNet 50, inspired by deep learning's success in image analysis.The suggested classifier approach allows the selection of relevant characteristics while avoiding overfitting issues.When the proposed algorithm was compared to the existing models, the results proved that it had better accuracy values.

Downloads

Download data is not yet available.

References

Zetterberg, Henrik, and Barbara B. Bendlin. "Biomarkers for Alzheimer’s disease—preparing for a new era of disease-modifying therapies." Molecular psychiatry 26, no. 1 (2021): 296-308.

Sanchez, Justin S., J. Alex Becker, Heidi IL Jacobs, Bernard J. Hanseeuw, Shu Jiang, Aaron P. Schultz, Michael J. Properzi et al. "The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography." Science translational medicine 13, no. 577 (2021): eabc0655.

Johansson, Maurits, Erik Stomrud, Philip S. Insel, Antoine Leuzy, Per Mårten Johansson, Ruben Smith, Zahinoor Ismail et al. "Mild behavioural impairment and its relation to tau pathology in preclinical Alzheimer’s disease." Translational psychiatry 11, no. 1 (2021): 1-8.

Leng, Kun, Emmy Li, Rana Eser, Antonia Pierogies, Rene Sit, Michelle Tan, Norma Neff et al. "Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease." Nature neuroscience 24, no. 2 (2021): 276-287.

Wightman, Douglas P., Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Dominic Holland, ArvidRongve et al. "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease." Nature genetics 53, no. 9 (2021): 1276-1282.

Nguyen, Phuong H., AyyalusamyRamamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez et al. "Amyloid oligomers: A joint experimental/computational perspective on Alzheimer’s disease, Parkinson’s disease, type II diabetes, and amyotrophic lateral sclerosis." Chemical reviews 121, no. 4 (2021): 2545-2647.

Karikari, Thomas K., Andrea L. Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, AnniinaSnellman, Marc Suarez-Calvet, Paramita Saha-Chaudhuri et al. "Diagnostic performance and prediction of clinical progression of plasma phosphor-tau181 in the Alzheimer’s Disease Neuroimaging Initiative." Molecular psychiatry 26, no. 2 (2021): 429-442.

Neff, Ryan A., Minghui Wang, SezenVatansever, Lei Guo, Chen Ming, Qian Wang, Erming Wang et al. "Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets." Science advances 7, no. 2 (2021): eabb5398.

Qiu, Chengxuan, MiiaKivipelto, and Eva Von Strauss. "Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention." Dialogues in clinical neuroscience (2022).

Dubois, Bruno, Gaetane Picard, and Marie Sarazin. "Early detection of Alzheimer's disease: new diagnostic criteria." Dialogues in clinical neuroscience (2022).

Gao, Shuangshuang, and Dimas Lima. "< PE-AT> A review of the application of deep learning in the detection of Alzheimer's disease." International Journal of Cognitive Computing in Engineering (2021).

Attallah, Omneya, Maha A. Sharkas, and HebaGadelkarim. "Deep learning techniques for automatic detection of embryonic neurodevelopmental disorders." Diagnostics 10, no. 1 (2020): 27.

Liu, Fei, Huabin Wang, Yonglin Chen, Yu Quan, and Liang Tao. "Convolutional neural network based on feature enhancement and attention mechanism for Alzheimer's disease prediction using MRI images." In Proc. of SPIE Vol, vol. 12083, pp. 120830X-1. 2022.

Loddo, Andrea, Sara Buttau, and Cecilia Di Ruberto. "Deep learning based pipelines for Alzheimer's disease diagnosis: a comparative study and a novel deep-ensemble method." Computers in biology and medicine 141 (2022): 105032.

A. Kaur and C. Singh, “Contrast enhancement for cephalometric images using wavelet-based modified adaptive histogram equalization,” Applied Soft Computing, vol. 51, pp. 180–191, 2017.

Shehroz S. Khan and Amir Ahmad, Cluster Centre Initialization Algorithm for K-means Cluster, In Pattern Recognition Letters, pp. 1293–1302, (2004).

D. Sonker, “Comparison of Histogram Equalization Techniques for Image Enhancement of Grayscale images in Natural and Unnatural light,” International Journal of Engineering Research and Development, vol. 8, no. 9, pp. 57–61, 2013.

Pizer SM, et.al (1990) “Contrast-limited adaptive histogram equalization: speed and effectiveness”, In Proceedings of the first conference on visualization in biomedical computing. IEEE, pp 337–345.

Aimi Salihai Abdul, MohdYusuffMasor and Zeehaida Mohamed, Colour Image Segmentation Approach for Detection of Malaria Parasite using Various Colour Models and k-Means Clustering, In WSEAS Transaction on Biology and Biomedicine., vol. 10, January (2013).

Hossain, Md Belal, SM Hasan Sazzad Iqbal, Md Monirul Islam, Md Nasim Akhtar, and Iqbal H. Sarker. "Transfer learning with fine-tuned deep CNN ResNet50 model for classifying COVID-19 from chest X-ray images." Informatics in Medicine Unlocked (2022): 100916.

.Alsabhan, Waleed, and TurkyAlotaiby. "Automatic Building Extraction on Satellite Images Using Unet and ResNet50." Computational Intelligence and Neuroscience 2022 (2022).

Saadna, Youness, AnouarAbdelhakimBoudhir, and Mohamed Ben Ahmed. "An Analysis of ResNet50 Model and RMSprop Optimizer for Education Platform Using an Intelligent Chatbot System." In Networking, Intelligent Systems and Security, pp. 577-590. Springer, Singapore, 2022.

Beheshti, I., Demirel, H., Matsuda, H., Initiative, A.D.N., et al.: Classification of Alzheimer’s disease and prediction of mild cognitive impairment-to-Alzheimer’s conversion from structural magnetic resource imaging using feature ranking and a genetic algorithm. Comput. Biol. Med. 83, 109–119 (2017).

Suk, H.I., Lee, S.W., Shen, D.: Deep ensemble learning of sparse regression models for brain disease diagnosis. Med. Image Anal. 37, 101–113 (2017).

Shi, B., et al.: Nonlinear feature transformation and deep fusion for Alzheimer’s disease staging analysis. Pattern Recognit. 63, 487–498 (2017).

Liu, M., Zhang, D., Shen, D., Alzheimer’s Disease Neuroimaging Initiative: Hierarchical fusion of features and classifier decisions for Alzheimer’s disease diagnosis. Hum. Brain Mapp. 35(4), 1305–1319 (2014).

Aderghal, K., Benois-Pineau, J., Afdel, K.: Classification of SMRI for Alzheimer’s disease diagnosis with CNN: single Siamese networks with 2d+? approach and fusion on ADNI. In: Proceedings of the 2017 ACM on International Conference on Multimedia Retrieval, pp. 494–498. ACM (2017).

Islam, Jyoti, Yanqing Zhang, and Alzheimer’s Disease Neuroimaging Initiative. "Deep convolutional neural networks for automated diagnosis of Alzheimer’s disease and mild cognitive impairment using 3D brain MRI." In International Conference on Brain Informatics, pp. 359-369. Springer, Cham, 2018.

Neurons in the brain display microscopic plaques and tangles in Alzheimer's illness

Downloads

Published

19.12.2022

How to Cite

Nithya V. P., N. Mohanasundaram, & R. Santhosh. (2022). Cad System for the Detection and Classification of Alzheimers From Mr Images Using Deep Learning Techniques. International Journal of Intelligent Systems and Applications in Engineering, 10(2s), 96–104. Retrieved from https://ijisae.org/index.php/IJISAE/article/view/2368

Issue

Section

Research Article