Enhancing Oral Squamous Cell Carcinoma Detection: A Transfer Learning Perspective on Histopathological Analysis Using ResNet-18, AlexNet, DenseNet-169, and DenseNet-201 with Cyclic Learning Rate

Authors

  • Aarti Yadav Research Scholar Department of Computer Science Engineering Vivekananda global university, Jaipur (Raj), India
  • Surendra Yadav Professor Department of Computer Science Engineering Vivekananda global university, Jaipur (Raj), India

Keywords:

Oral squamous cell carcinoma, histopathologic analysis, transfer learning, deep learning, Convolutional Neural Network

Abstract

: In this study, an innovative method is introduced for the early identification of Oral Squamous Cell Carcinoma (OSCC) by employing deep learning techniques to analyze histopathological samples. Four prominent neural network architectures, ResNet-18, AlexNet, DenseNet-169, and DenseNet-201, are utilized to scrutinize biopsy specimens for cancerous anomalies. The approach incorporates Cyclic Learning Rate (CLR) for dynamic adaptation of learning rates during the model's training. ResNet-18 benefits from skip connections to enhance gradient flow, while AlexNet and DenseNet architectures significantly contribute to precise image categorization. DenseNet's distinctive feature reuse mechanism effectively mitigates the vanishing gradient issue. The research underscores the potential of deep learning in enhancing early OSCC detection, offering a promising avenue for more efficient cancer screening and treatment.

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References

Basu, K., Sinha, R., Ong, A., & Basu, T. (2020). Artificial intelligence: How is it changing medical sciences and its future?. Indian journal of dermatology, 65(5), 365.

Bishnoi, L., & Singh, S. N. (2018, January). Artificial intelligence techniques used in medical sciences: a review. In 2018 8th international conference on cloud computing, data science & engineering (Confluence) (pp. 1-8). IEEE.

Guan, J. (2019). Artificial intelligence in healthcare and medicine: promises, ethical challenges and governance. Chinese Medical Sciences Journal, 34(2), 76-83.

Winkler-Schwartz, A., Bissonnette, V., Mirchi, N., Ponnudurai, N., Yilmaz, R., Ledwos, N., ... & Del Maestro, R. F. (2019). Artificial intelligence in medical education: best practices using machine learning to assess surgical expertise in virtual reality simulation. Journal of surgical education, 76(6), 1681-1690.

Chai, A. W. Y., Lim, K. P., & Cheong, S. C. (2020, April). Translational genomics and recent advances in oral squamous cell carcinoma. In Seminars in cancer biology (Vol. 61, pp. 71-83). Academic Press.

Warin, K., Limprasert, W., Suebnukarn, S., Jinaporntham, S., Jantana, P., & Vicharueang, S. (2022). AI-based analysis of oral lesions using novel deep convolutional neural networks for early detection of oral cancer. PloS One, 17(8), e0273508. doi:10.1371/journal.pone.0273508

Mentel, S., Gallo, K., Wagendorf, O., Preissner, R., Nahles, S., Heiland, M., & Preissner, S. (2021). Prediction of oral squamous cell carcinoma based on machine learning of breath samples: a prospective controlled study. BMC Oral Health, 21(1), 500. doi:10.1186/s12903-021-01862-z

Alabi, R. O., Bello, I. O., Youssef, O., Elmusrati, M., Mäkitie, A. A., & Almangush, A. (2021). Utilizing deep machine learning for prognostication of oral squamous cell carcinoma-A systematic review. Frontiers in Oral Health, 2, 686863. doi:10.3389/froh.2021.686863

Musulin, J., Štifanić, D., Zulijani, A., Ćabov, T., Dekanić, A., & Car, Z. (2021). An enhanced histopathology analysis: An AI-based system for multiclass grading of oral squamous cell carcinoma and segmenting of epithelial and stromal tissue. Cancers, 13(8), 1784. doi:10.3390/cancers13081784

Jubair, F., Al-Karadsheh, O., Malamos, D., Al Mahdi, S., Saad, Y., & Hassona, Y. (2022). A novel lightweight deep convolutional neural network for early detection of oral cancer. Oral Diseases, 28(4), 1123–1130. https://doi.org/10.1111/odi.13825

Rahman, A.-U., Alqahtani, A., Aldhafferi, N., Nasir, M. U., Khan, M. F., Khan, M. A., & Mosavi, A. (2022). Histopathologic oral cancer prediction using oral squamous cell carcinoma biopsy empowered with transfer learning. Sensors (Basel, Switzerland), 22(10), 3833. https://doi.org/10.3390/s22103833

Torabi, Molook, et al. “Correlation between Clinical and Histopathologic Diagnosis of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma.” Pesquisa Brasileira Em Odontopediatria e Clinica Integrada, vol. 21, 2021, p. e0143, doi:10.1590/pboci.2021.068.

Rivera, César, and Bernardo Venegas. “Histological and Molecular Aspects of Oral Squamous Cell Carcinoma (Review).” Oncology Letters, vol. 8, no. 1, 2014, pp. 7–11, doi:10.3892/ol.2014.2103.

Terada, Tadashi. “Verrucous Carcinoma of the Oral Cavity: A Histopathologic Study of 10 Japanese Cases.” Journal of Maxillofacial and Oral Surgery, vol. 10, no. 2, 2011, pp. 148–151, doi:10.1007/s12663-011-0197-x.

Yu, Ryan, et al. “Pseudoglandular Squamous Cell Carcinoma.” Cutis; Cutaneous Medicine for the Practitioner, vol. 95, no. 2, 2015, pp. 68, 104–6, https://www.mdedge.com/dermatology/article/97147/dermatopathology/pseudoglandular-squamous-cell-carcinoma.

Raut, T., et al. “Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva.” Case Reports in Dentistry, vol. 2021, 2021, p. 5570092, doi:10.1155/2021/5570092.

Kim, Bo Young, et al. “Sarcomatoid Carcinoma after Radiotherapy for Early-Stage Oral Squamous Cell Carcinoma: Case Report: Case Report.” Medicine, vol. 98, no. 27, 2019, p. e16003, doi:10.1097/MD.0000000000016003.

Eguchi, Takanori, et al. “Adenosquamous Carcinoma Development as a Recurrence of Squamous Cell Carcinoma in the Oral Floor: A Case Report: A Case Report.” Medicine, vol. 98, no. 43, 2019, p. e17688, doi:10.1097/MD.0000000000017688.

Gupta, Bhavana, et al. “Basaloid Squamous Cell Carcinoma - A Rare and Aggressive Variant of Squamous Cell Carcinoma: A Case Report and Review of Literature.” National Journal of Maxillofacial Surgery, vol. 9, no. 1, 2018, pp. 64–68, doi:10.4103/njms.NJMS_14_17.

Wang, Yong, et al. “Papillary Squamous Cell Carcinoma Successfully Treated with Bronchoscopic Intratumoral Injections of Cisplatin and Endostar: A Case Report.” The Journal of International Medical Research, vol. 49, no. 9, 2021, p. 3000605211047077, doi:10.1177/03000605211047077.

Alabi, Rasheed Omobolaji, et al. “Machine Learning in Oral Squamous Cell Carcinoma: Current Status, Clinical Concerns and Prospects for Future-A Systematic Review.” Artificial Intelligence in Medicine, vol. 115, no. 102060, 2021, p. 102060, doi:10.1016/j.artmed.2021.102060.

Mentel, Sophia, et al. “Prediction of Oral Squamous Cell Carcinoma Based on Machine Learning of Breath Samples: A Prospective Controlled Study.” BMC Oral Health, vol. 21, no. 1, 2021, p. 500, doi:10.1186/s12903-021-01862-z.

Tseng, Yi-Ju, et al. “Development and Validation of Machine Learning-Based Risk Prediction Models of Oral Squamous Cell Carcinoma Using Salivary Autoantibody Biomarkers.” BMC Oral Health, vol. 22, no. 1, 2022, p. 534, doi:10.1186/s12903-022-02607-2.

Chiesa-Estomba, Carlos M., et al. “Machine Learning Algorithms as a Computer-Assisted Decision Tool for Oral Cancer Prognosis and Management Decisions: A Systematic Review.” ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties, vol. 84, no. 4, 2022, pp. 278–288, doi:10.1159/000520672.

Alabi, Rasheed Omobolaji, et al. “Deep Machine Learning for Oral Cancer: From Precise Diagnosis to Precision Medicine.” Frontiers in Oral Health, vol. 2, 2021, p. 794248, doi:10.3389/froh.2021.794248.

Musulin, Jelena, et al. “Automated Grading of Oral Squamous Cell Carcinoma into Multiple Classes Using Deep Learning Methods.” 2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE), IEEE, 2021, pp. 1–6.

Alanazi, Adwan A., et al. “Intelligent Deep Learning Enabled Oral Squamous Cell Carcinoma Detection and Classification Using Biomedical Images.” Computational Intelligence and Neuroscience, vol. 2022, 2022, p. 7643967, doi:10.1155/2022/7643967.

Deif, Mohanad A., et al. “Diagnosis of Oral Squamous Cell Carcinoma Using Deep Neural Networks and Binary Particle Swarm Optimization on Histopathological Images: An AIoMT Approach.” Computational Intelligence and Neuroscience, vol. 2022, 2022, p. 6364102, doi:10.1155/2022/6364102.

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Published

23.02.2024

How to Cite

Yadav, A. ., & Yadav, S. . (2024). Enhancing Oral Squamous Cell Carcinoma Detection: A Transfer Learning Perspective on Histopathological Analysis Using ResNet-18, AlexNet, DenseNet-169, and DenseNet-201 with Cyclic Learning Rate. International Journal of Intelligent Systems and Applications in Engineering, 12(17s), 689–699. Retrieved from https://ijisae.org/index.php/IJISAE/article/view/4937

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Research Article