Cancer XAI: A Responsible Model for Explaining Cancer Drug Prediction Models
Keywords:
Artificial Intelligence, Explainable AI, Ensemble Model, Random Forest Classifier, XAIAbstract
There has been a growing interest in using Explainable Artificial Intelligence (XAI) for healthcare in recent years. An explainable artificial intelligence (XAI) model for cancer diagnosis is suggested in this research paper. The model offers data that can be understood and explained, essential for medical decision-making. It also makes reliable forecasts. Compared to other models, the proposed model performs at the cutting edge thanks to training and evaluation on a sizable dataset of cancer images. The significance of interpretability in medical applications is also covered in the paper, along with how the suggested model resolves this issue. The findings of this study show how XAI models have the potential to increase cancer detection and provide more transparent and reliable medical decision-making.
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J. AMANN, A. BLASIMME, E. VAYENA, D. FREY, AND V. I. MADAI, “EXPLAINABILITY FOR ARTIFICIAL INTELLIGENCE IN HEALTHCARE: A MULTIDISCIPLINARY PERSPECTIVE,” BMC MEDICAL INFORMATICS AND DECISION MAKING, VOL. 20, NO. 1. SPRINGER SCIENCE AND BUSINESS MEDIA LLC, NOV. 30, 2020. DOI: 10.1186/S12911-020-01332-6.
P. GOHEL, P. SINGH, AND M. MOHANTY, “EXPLAINABLE AI: CURRENT STATUS AND FUTURE DIRECTIONS.” ARXIV, 2021. DOI: 10.48550/ARXIV.2107.07045.
Kikutsuji, Takuma & Mori, Yusuke & Okazaki, Kei-ichi & Mori, Toshifumi & Kim, Kang & Matubayasi, Nobuyuki. (2022). Explaining reaction coordinates of alanine dipeptide isomerization obtained from deep neural networks using Explainable Artificial Intelligence (XAI). https://doi.org/10.1063/5.0087310
Shuyun He, Duancheng Zhao, Yanle Ling, Hanxuan Cai, Yike Cai, Jiquan Zhang, Ling Wang. (2021). Machine Learning Enables Accurate and Rapid Prediction of Active Molecules Against Breast Cancer Cells.https://doi.org/10.3389/fphar.2021.796534
E. Tjoa and C. Guan, "A Survey on Explainable Artificial Intelligence (XAI): Toward Medical XAI," in IEEE Transactions on Neural Networks and Learning Systems, vol. 32, no. 11, pp. 4793-4813, Nov. 2021, doi: 10.1109/TNNLS.2020.3027314.
Jogani, Vinay & Purohit, Joy & Shivhare, Ishaan & Shrawne, Seema. (2022). Analysis of Explainable Artificial Intelligence Methods on Medical Image Classification. 10.48550/arXiv.2212.10565.
Tuncal, Kubra & Sekeroglu, Boran & Ozkan, Cagri. (2020). Lung Cancer Incidence Prediction Using Machine Learning Algorithms. Journal of Advances in Information Technology. 91-96. 10.12720/jait.11.2.91-96.
Gohel, Prashant, Priyanka Singh and Manoranjan Mohanty. “Explainable AI: current status and future directions.” ArXiv abs/2107.07045 (2021): n. Pag.
Gerlings, Julie & Jensen, Millie & Shollo, Arisa. (2022). Explainable AI, But Explainable to Whom - An Exploratory Case Study of xAI in Healthcare. https://doi:10.1007/978-3-030-83620-7_7
Sarveniazi, Alireza. (2014). An Actual Survey of Dimensionality Reduction. American Journal of Computational Mathematics. 04. 55-72. 10.4236/ajcm.2014.42006.
D. Delen, “Analysis of cancer data: a data mining approach,” Expert Systems, vol. 26, no. 1. Wiley, pp. 100–112, Feb. 2009. doi: 10.1111/j.1468-0394.2008.00480.x.
H. Lu, H. Wang, and S. W. Yoon, “A dynamic gradient boosting machine using genetic optimizer for practical breast cancer prognosis,” Expert Systems with Applications, vol. 116. Elsevier BV, pp. 340–350, Feb. 2019. doi: 10.1016/j.eswa.2018.08.040.
G. Alfian et al., “Blood glucose prediction model for type 1 diabetes based on artificial neural network with time-domain features,” Biocybernetics and Biomedical Engineering, vol. 40, no. 4. Elsevier BV, pp. 1586–1599, Oct. 2020. doi: 10.1016/j.bbe.2020.10.004.
S. K. Kwak and J. H. Kim, “Statistical data preparation: management of missing values and outliers,” Korean Journal of Anesthesiology, vol. 70, no. 4. The Korean Society of Anesthesiologists, p. 407, 2017. doi: 10.4097/kjae.2017.70.4.407.
J. Miao and L. Niu, “A Survey on Feature Selection,” Procedia Computer Science, vol. 91. Elsevier BV, pp. 919–926, 2016. doi: 10.1016/j.procs.2016.07.111.
I. Jebadurai Johnraja, G. Paulraj Jeba, J. Jebadurai, and S. Silas, “Experimental analysis of filtering-based feature selection techniques for fetal health classification,” Serbian Journal of Electrical Engineering, vol. 19, no. 2. National Library of Serbia, pp. 207–224, 2022. doi: 10.2298/sjee2202207j.
I. Guyon, J. Weston, S. Barnhill, and V. Vapnik, Machine Learning, vol. 46, no. 1/3. Springer Science and Business Media LLC, pp. 389–422, 2002. doi: 10.1023/a:1012487302797.
X. Chen and J. C. Jeong, “Enhanced recursive feature elimination,” Sixth International Conference on Machine Learning and Applications (ICMLA 2007). IEEE, Dec. 2007. doi: 10.1109/icmla.2007.35.
D. Elavarasan, D. R. Vincent P M, K. Srinivasan, and C.-Y. Chang, “A Hybrid CFS Filter and RF-RFE Wrapper-Based Feature Extraction for Enhanced Agricultural Crop Yield Prediction Modeling,” Agriculture, vol. 10, no. 9. MDPI AG, p. 400, Sep. 11, 2020. doi: 10.3390/agriculture10090400.
C. N. and P. A. Vijaya, “Machine Learning Based Comparison of Pearson’s and Partial Correlation Measures to Quantify Functional Connectivity in the Human Brain,” International Journal of Neuroscience and Behavioral Science, vol. 6, no. 3. Horizon Research Publishing Co., Ltd., pp. 23–30, Jun. 2018. doi: 10.13189/ijnbs.2018.060301.
J. Jiang, L.-C. Xu, F. Li, and J. Shao, “Machine Learning Potential Model Based on Ensemble Bispectrum Feature Selection and Its Applicability Analysis,” Metals, vol. 13, no. 1. MDPI AG, p. 169, Jan. 13, 2023. doi: 10.3390/met13010169.
Y. Saeys, I. Inza, and P. Larrañaga, “A review of feature selection techniques in bioinformatics,” Bioinformatics, vol. 23, no. 19. Oxford University Press (OUP), pp. 2507–2517, Aug. 24, 2007. doi: 10.1093/bioinformatics/btm344.
Y. Saeys, T. Abeel, and Y. Van de Peer, “Robust Feature Selection Using Ensemble Feature Selection Techniques,” Machine Learning and Knowledge Discovery in Databases. Springer Berlin Heidelberg, pp. 313–325, 2008. doi: 10.1007/978-3-540-87481-2_21.
Y. Li, S. Gao, and S. Chen, “Ensemble Feature Weighting Based on Local Learning and Diversity,” Proceedings of the AAAI Conference on Artificial Intelligence, vol. 26, no. 1. Association for the Advancement of Artificial Intelligence (AAAI), pp. 1019–1025, Sep. 20, 2021. doi: 10.1609/aaai.v26i1.8275.
U. Neumann, N. Genze, and D. Heider, “EFS: an ensemble feature selection tool implemented as R-package and web-application,” BioData Mining, vol. 10, no. 1. Springer Science and Business Media LLC, Jun. 27, 2017. doi: 10.1186/s13040-017-0142-8.
Y. Saeys, T. Abeel, and Y. Van de Peer, “Robust Feature Selection Using Ensemble Feature Selection Techniques,” Machine Learning and Knowledge Discovery in Databases. Springer Berlin Heidelberg, pp. 313–325, 2008. doi: 10.1007/978-3-540-87481-2_21.
N. Kuhnert, R. Jaiswal, P. Eravuchira, R. M. El-Abassy, B. von der Kammer, and A. Materny, “Scope and limitations of principal component analysis of high resolution LC-TOF-MS data: the analysis of the chlorogenic acid fraction in green coffee beans as a case study,” Anal. Methods, vol. 3, no. 1. Royal Society of Chemistry (RSC), pp. 144–155, 2011. doi: 10.1039/c0ay00512f.
D. Samariya, J. Ma, S. Aryal, and X. Zhao, “Detection and explanation of anomalies in healthcare data,” Health Information Science and Systems, vol. 11, no. 1. Springer Science and Business Media LLC, Apr. 06, 2023. doi: 10.1007/s13755-023-00221-2.
G. Biau and E. Scornet, “A random forest guided tour,” TEST, vol. 25, no. 2. Springer Science and Business Media LLC, pp. 197–227, Apr. 19, 2016. doi: 10.1007/s11749-016-0481-7.
Y. Xu, Z. Cao, and M. Wang, “Analysis of factors influencing regional economic expansion based on OOB coefficients under RF algorithm,” BCP Business & Management, vol. 33. Boya Century Publishing, pp. 242–249, Nov. 20, 2022. doi: 10.54691/bcpbm.v33i.2753.
C. Suriyanarayanan and S. Kunasekaran, “Anomaly detection using machine learning techniques,” Malaya Journal of Matematik, vol. 8, no. 4. MKD Publishing House, pp. 2144–2148, 2020. doi: 10.26637/mjm0804/0139.
N. Lutimath, N. Sharma, and B. K, “Prediction of Heart Disease using Biomedical Data through Machine Learning Techniques,” EAI Endorsed Transactions on Pervasive Health and Technology—European Alliance for Innovation n.o., p. 170881, Jul. 13, 2018. doi: 10.4108/eai.30-8-2021.170881.
J. Liang, “Image classification based on RESNET,” Journal of Physics: Conference Series, vol. 1634, no. 1. IOP Publishing, p. 012110, Sep. 01, 2020. doi: 10.1088/1742-6596/1634/1/012110.
H.-S. Choi, K. An, and M. Kang, “Regression with residual neural network for vanishing point detection,” Image and Vision Computing, vol. 91. Elsevier BV, p. 103797, Nov. 2019. doi: 10.1016/j.imavis.2019.08.001.
A. Chaddad, J. Peng, J. Xu, and A. Bouridane, “Survey of Explainable AI Techniques in Healthcare,” Sensors, vol. 23, no. 2, p. 634, Jan. 2023, doi: 10.3390/s23020634.
Abraham, A. T., & Fredrik, E. J. T. . (2023). Integrating the EGC, EF, and ECS Trio Approaches to Ensure Security and Load Balancing in the Cloud. International Journal on Recent and Innovation Trends in Computing and Communication, 11(4s), 100–108. https://doi.org/10.17762/ijritcc.v11i4s.6312
Pande, S. D., Kanna, R. K., & Qureshi, I. (2022). Natural Language Processing Based on Name Entity With N-Gram Classifier Machine Learning Process Through GE-Based Hidden Markov Model. Machine Learning Applications in Engineering Education and Management, 2(1), 30–39. Retrieved from http://yashikajournals.com/index.php/mlaeem/article/view/22
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