Advancing Alzheimer's Disease Detection: Integrating Machine Learning And Image Analysis For Accurate Diagnosis

Authors

  • Archana Gopinadhan Research Scholar, Department of Computer Science, AJK College of Arts and Science, Coimbatore- 641 105
  • Angeline Prasanna G. Former Associate Professor and Head, Department of Computer Science, AJK College of Arts and Science Coimbatore- 641 105.

Keywords:

AD, CNN, Classification, EADD, MLP, RESNet150

Abstract

Alzheimer's disease (AD) has a beneficial global impact on human life despite being a difficult, incurable, and horrible condition. Since it was not preventable by immunization, it was the sixth leading cause of death in the USA. The toughest part of finding new organisms. Understanding the cause of AD and finding ways to prevent or cure it will benefit from the discovery of proteins and genes involved in the illness. They employ practical tools and expertise to investigate the possible interaction between genes/proteins with Alzheimer's. Current information from all known AD proteins/genes was utilized to construct a machine-learning method for protein-connection prediction in Alzheimer's disease. Since MR brain scans are often used for diagnosing Alzheimer's, we suggested the EADD (Enhanced Alzheimer's Disease Detection) method. Multi-layer perceptual (MLP) was used to filter out the background noise in the MRI data set. In this proposed study, we use Histogram equalization to improve images, the Edge-based Robert operator to segment them, CNN with RESNet150 to train them, and the CNN Algorithm to classify them. Based on experimental data, the suggested method in this study has a classification accuracy of up to 98%.

Downloads

Download data is not yet available.

References

Akhila D B, Shobhana S, Fred, A. L., & Kumar, S. . (2016). Robust Alzheimer's disease classification based on multimodal neuroimaging. 2016 IEEE International Conference on Engineering and Technology (ICETECH). doi:10.1109/icetech.2016.7569348

Burgmans, S., van de Haar, H., van Osch, M., Jansen, J., van Buchem, M., Hofman, P., … Backes, W. (2014). Blood-Brain Barrier Leakage In Alzheimer's Disease: A Dynamic Contrast-Enhanced MRI Study. Alzheimer's & Dementia, 10(4), P101. doi:10.1016/j.jalz.2014.05.188

A, S., Battacharjee, P., Prasad I, A., & Sanyal, G. (2018). Brain MR Image Analysis using Discrete wavelet Transform with Fractal Feature Analysis. 2018 Second International Conference on Electronics, Communication and Aerospace Technology (ICECA). doi:10.1109/iceca.2018.8474806

Beagum, S. S., Almas, A. A., & Sheeja, S. (2016). Alzheimer's disease, bio-markers, and the role of classification techniques in early diagnosis from neuro-images — An analysis. 2016 IEEE International Conference on Computational Intelligence and Computing Research (ICCIC). doi:10.1109/iccic.2016.7919701

Bakkouri, I., Afdel, K., Benois-Pineau, J., & Catheline, G. (2019). Recognition of Alzheimer's Disease on sMRI based on 3D Multi-Scale CNN Features and a Gated Recurrent Fusion Unit. 2019 International Conference on Content-Based Multimedia Indexing (CBMI). doi:10.1109/cbmi.2019.8877477

Burgmans, S., van de Haar, H., van Osch, M., Jansen, J., van Buchem, M., Hofman, P., … Backes, W. (2014). Blood-Brain-Barrier Leakage In Alzheimer's Disease: A Dynamic Contrast-Enhanced MRI Study. Alzheimer's & Dementia, 10(4), P557. doi:10.1016/j.jalz.2014.05.903

Blanchette, R., Khojandi, A., Cox, D., Oliver, M., & Fernandez, R. (2020). Predicting Alzheimer's Disease Using Driving Simulator Data. 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). doi:10.1109/embc44109.2020.9176118

Chelsy Sapna Josephus, & Remya, S. (2011). Multilayered Contrast Limited Adaptive Histogram Equalization Using Frost Filter. 2011 IEEE Recent Advances in Intelligent Computational Systems. doi:10.1109/raics.2011.6069388

Chauhan, G., Adams, H. H. H., Bis, J., Weinstein, G., Yu, L., Smith, A., … Debette, S. (2014). Association Of Alzheimer Disease Gwas Loci With MRI-Markers Of Brain Aging. Alzheimer's & Dementia, 10(4), P258. doi:10.1016/j.jalz.2014.04.406

Matthews, D. C., Andrews, R. D., Lukic, A. S., Mishra, V. R., Banks, S. J., Cummings, J. L., & Bernick, C. (2018). MRI Classifiers Characterize Mild Traumatic Brain Injury In Symptomatic And Presymptomatic Stages And Differentiate From Alzheimer's Disease–Related Impairment. Alzheimer's & Dementia, 14(7), P443–P445. doi:10.1016/j.jalz.2018.06.388

Fedorov, A., Hjelm, R. D., Abrol, A., Fu, Z., Du, Y., Plis, S., & Calhoun, V. D. (2019). Prediction of Progression to Alzheimer's disease with Deep InfoMax. 2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI). doi:10.1109/bhi.2019.8834630

Falangola, M. F., Jensen, J. H., Tabesh, A., Hu, C., Deardorff, R. L., Babb, J. S., … Helpern, J. A. (2013). Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer's disease. Magnetic Resonance Imaging, 31(6), 840–846. doi:10.1016/j.mri.2013.02.008

Gunawardena, K. A. N. N. P., Rajapakse, R. N., & Kodikara, N. D. (2017). Applying convolutional neural networks for pre-detection of alzheimer's disease from structural MRI data. 2017 24th International Conference on Mechatronics and Machine Vision in Practice (M2VIP). doi:10.1109/m2vip.2017.8211486

Herrera, L. J., Rojas, I., Pomares, H., Guillen, A., Valenzuela, O., & Banos, O. (2013). Classification of MRI Images for Alzheimer's Disease Detection. 2013 International Conference on Social Computing. doi:10.1109/socialcom.2013.127

Jang, J.-W., Park, S. Y., Park, Y. H., Baek, M. J., Lim, J.-S., Youn, Y. C., & Kim, S. (2014). A Comprehensive Visual Rating Scale On Brain MRI: Application To Alzheimer's Disease, Mild Cognitive Impairment, And Subjective Memory Impairment. Alzheimer's & Dementia, 10(4), P714. doi:10.1016/j.jalz.2014.05.1319

Josephs, K. A., Dickson, D. W., Murray, M. E., Senjem, M. L., Parisi, J. E., Petersen, R. C., … Whitwell, J. L. (2013). Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia. Brain and Language, 127(2), 127–134. doi:10.1016/j.bandl.2013.02.003

Kaur, H., & Rani, J. (2016). MRI brain image enhancement using Histogram Equalization techniques. 2016 International Conference on Wireless Communications, Signal Processing and Networking (WiSPNET). doi:10.1109/wispnet.2016.7566237

Li, C., Fang, C., Adjouadi, M., Cabrerizo, M., Barreto, A., Andrian, J., … Loewenstein, D. (2017). A Neuroimaging Feature Extraction Model for Imaging Genetics with Application to Alzheimer's Disease. 2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE). doi:10.1109/bibe.2017.00-85

Matthews, D. C., Andrews, R. D., Lukic, A. S., Mishra, V. R., Banks, S. J., Cummings, J. L., & Bernick, C. (2018). MRI Classifiers Characterize Mild Traumatic Brain Injury In Symptomatic And Presymptomatic Stages And

Mukhopadhyay, S., Ghosh, N., Burman, R., Panigrahi, P. K., Pratiher, S., Venkatesh, M., … Changdar, S. (2015). An optimized hyper kurtosis based modified duo-histogram equalization (HKMDHE) method for contrast enhancement purpose of low contrast human brain CT scan images. 2015 International Conference on Advances in Computing, Communications and Informatics (ICACCI). doi:10.1109/icacci.2015.7275880

Niemantsverdriet, E., Struyfs, H., Van Hecke, W., Smeets, D., & Engelborghs, S. (2016). Volumetric Brain Mri Of Different Regions, Including The Hippocampus, In The Alzheimer's Disease Spectrum: A Systematic Review. Alzheimer's & Dementia, 12(7), P547–P548. doi:10.1016/j.jalz.2016.06.1071

Prins, N., Benedictus, M., Binnewijzend, M., Scheltens, P., Barkhof, F., & Van der Flier, W. (2012). Cerebral blood flow, measured with ASL perfusion MRI at 3T, and structural brain changes in Alzheimer's disease. Alzheimer's & Dementia, 8(4), P737. doi:10.1016/j.jalz.2012.05.1988

Sathish Kumar, L., Hariharasitaraman, S., Narayanasamy, K., Thinakaran, K., Mahalakshmi, J., & Pandimurugan, V. (2021). AlexNet approach for early stage Alzheimer's disease detection from MRI brain images. Materials Today: Proceedings. doi:10.1016/j.matpr.2021.04.415

Sarraf, S., & Tofighi, G. (2016). Deep learning-based pipeline to recognize Alzheimer's disease using fMRI data. 2016 Future Technologies Conference (FTC). doi:10.1109/ftc.2016.7821697

Seo, K., Pan, R., Chen, K., & Thiyyagura, P. (2017). Tracking alzheimer's disease progression by non-linear dimension reduction of brain mri features. Alzheimer's & Dementia, 13(7), P349–P350. doi:10.1016/j.jalz.2017.06.277

Shi, L., Wong, L., Liu, J., Wang, D., Li, K., & Liang, P. (2019). MRI-Based Brain Volumetry In Single- And Multi-Domain Amnestic Mild Cognitive Impairment And Alzheimer's Disease. Alzheimer's & Dementia, 15(7), P712–P713. doi:10.1016/j.jalz.2019.06.2733

Starr, J. M., Farrall, A. J., Armitage, P., McGurn, B., & Wardlaw, J. (2009). Blood–brain barrier permeability in Alzheimer's disease: a case–control MRI study. Psychiatry Research: Neuroimaging, 171(3), 232–241. doi:10.1016/j.pscychresns.2008.04.003

Tanchi, C., Theera-Umpon, N., & Auephanwiriyakul, S. (2012). Fully automatic brain segmentation for Alzheimer's disease detection from magnetic resonance images. The 6th International Conference on Soft Computing and Intelligent Systems, and The 13th International Symposium on Advanced Intelligence Systems. doi:10.1109/scis-isis.2012.6505333

Venkataramanan, S., & Kalpakam, N. V. (n.d.). Aiding the detection of Alzheimer's disease in clinical electroencephalogram recording by selective de-noising of ocular artifacts. 2004 International Conference on Communications, Circuits and Systems (IEEE Cat. No.04EX914). doi:10.1109/icccas.2004.1346340

Wurts, A., Oakley, D. H., Hyman, B. T., & Samsi, S. (2020). Segmentation of Tau Stained Alzheimers Brain Tissue Using Convolutional Neural Networks. 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). doi:10.1109/embc44109.2020.917583

Wang, S., Wang, H., Shen, Y., & Wang, X. (2018). Automatic Recognition of Mild Cognitive Impairment and Alzheimers Disease Using Ensemble based 3D Densely Connected Convolutional Networks. 2018 17th IEEE International Conference on Machine Learning and Applications (ICMLA). doi:10.1109/icmla.2018.00083

Yablonskiy, D. A., Zhao, Y., Cairns, N. J., Hassenstab, J., Benzinger, T. L., Astafiev, S. V., … Morris, J. C. (2017). Gradient Echo Plural Contrast Mri Provides New Surrogate Markers Of Brain Pathology In Alzheimer's Disease. Alzheimer's & Dementia, 13(7), P127–P128. doi:10.1016/j.jalz.2017.06.2544

Yablonskiy, D. A., Zhao, Y., Cairns, N. J., Hassenstab, J., Benzinger, T. L. S., Astafiev, S. V., … Morris, J. C. (2017). Gradient Echo Plural Contrast Mri Provides New Surrogate Markers Of Brain Pathology In Alzheimer's Disease. Alzheimer's & Dementia, 13(7), P780. doi:10.1016/j.jalz.2017.06.1048

Downloads

Published

05.12.2023

How to Cite

Gopinadhan, A. ., & Prasanna G., A. . (2023). Advancing Alzheimer’s Disease Detection: Integrating Machine Learning And Image Analysis For Accurate Diagnosis. International Journal of Intelligent Systems and Applications in Engineering, 12(7s), 350–363. Retrieved from https://ijisae.org/index.php/IJISAE/article/view/4079

Issue

Section

Research Article