Prediction of Alzheimer's disease Using Stacked Ensemble Transfer Neural Network Model
Keywords:
Brain imaging; convolutional neural network (CNN); Alzheimer’s disease; pre-trained model; Ensemble learningAbstract
It is studied that Alzheimer's disease (AD) is growing fast and main cause of the death for the elderly people. Early detection of Alzheimer's disease has been proven to enhance patient outcomes. Machine learning techniques that utilize magnetic resonance imaging (MRI) have been used for AD diagnosis, but traditional methods require manual feature extraction by an expert, which can be complex. To address this, our study proposes a new approach using a pre-trained convolutional neural network called Stacked Ensemble Transferred Neural Network (SETNN) model for automated features extraction when using MRI images to detect Alzheimer's disease. The effectiveness of the SETNN model was assessed using a number of criteria, including accuracy, in comparison to traditional Softmax and support vector machine (SVM) techniques. The outcomes shown that, when applied to the MRI images from the ADNI dataset, the proposed SETNN model outperformed existing state-of-the-art models, achieving 99.49% accuracy. The developed model shall improve the prediction efficiency and decision making with early detection of Alzheimer.
Downloads
References
Loddo, A., Buttau, S., & Di Ruberto, C. (2022). Deep learning based pipelines for Alzheimer’s disease diagnosis: A comparative study and a novel deep-ensemble method. Computers in Biology and Medicine, 141, 1-15.
Mahendran, N., & PM, D. R. V. (2022). A deep learning framework with an embedded-based feature selection approach for the early detection of Alzheimer’s disease. Computers in Biology and Medicine, 141(September 2021).
Sava¸s, S. (2022). Detecting the stages of Alzheimer’s disease with pre-trained deep learning architectures. Arabian Journal for Science and Engineering, 47(2), 2201-2218.
Murugan, S., Venkatesan, C., Sumithra, M. G., Gao, X. Z., Elakkiya, B., et al. (2021). DEMNET: A deep learning model for early diagnosis of Alzheimer diseases and dementia from MR images. IEEE Access, 9, 90319-90329.
Mohammed, B. A., Senan, E. M., Rassem, T. H., Makbol, N. M., Alanazi, A. A., et al. (2021). Multi-method analysis of medical records and MRI images for early diagnosis of dementia and Alzheimer’s disease based on deep learning and hybrid methods. Electronics, 10, 1-20.
Gharaibeh, M., Almahmoud, M., Ali, M. Z., Al-Badarneh, A., El-Heis, M., et al. (2022). Early diagnosis of Alzheimer’s disease using cerebral catheter angiogram neuroimaging: A novel model based on deep learning approaches. Big Data and Cognitive Computing, 6(2), 1-23.
Basher, A., Kim, B. C., Lee, K. H., & Jung, H. Y. (2021). Volumetric feature-based Alzheimer’s disease diagnosis from sMRI data using a convolutional neural network and a deep neural network. IEEE Access, 9, 29870-29882.
Mirzaei, G., & Adeli, H. (2022). Machine learning techniques for diagnosis of Alzheimer disease, mild cognitive disorder, and other types of dementia. Biomedical Signal Processing and Control, 72.
Dadar, M., Pascoal, T. A., Manitsirikul, S., Misquitta, K., Fonov, V. S., et al. (2017). Validation of a regression technique for segmentation of white matter hyperintensities in Alzheimer’s disease. IEEE Transactions on Medical Imaging, 36(8), 1758-1768.
Lei, B., Liang, E., Yang, M., Yang, P., Zhou, F., et al. (2022). Predicting clinical scores for Alzheimer’s disease based on joint and deep learning. Expert Systems with Applications, 187.
Islam, J., & Zhang, Y. (2018). Early diagnosis of Alzheimer’s disease: A neuroimaging study with deep learning architectures. In IEEE Conf. on Computer Vision and Pattern Recognition Workshops, Salt Lake City, USA, pp. 1994-1996.
Ninni Persson, Paolo Ghisletta, Cheryl L. Dahle, Andrew R. Bender, Yiqin Yang, Peng Yuan, Ana M. Daugherty, Naftali Raz, Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factors, NeuroImage, Volume 126, 2016, Pages 15-26, ISSN 1053-8119, https://doi.org/10.1016/j.neuroimage.2015.11.028.
Sheng, J., Xin, Y., Zhang, Q. et al. Predictive classification of Alzheimer’s disease using brain imaging and genetic data. Sci Rep 12, 2405 (2022). https://doi.org/10.1038/s41598-022-06444-9.
Ding, X., Yang, Y., Steinbach, M., & Fujimoto, K. (2019). Hierarchical 3D deep convolutional neural networks for segmenting layered tubular structures in 3D images. IEEE Transactions on Medical Imaging, 38(1), 116-126.
Padilla, P., Lopez, M., Gorriz, J. M., Ramirez, J., Salas-Gonzalez, D., et al. "NMF-SVM based CAD tool applied to functional brain images for the diagnosis of Alzheimer’s disease." IEEE Transactions on Medical Imaging, vol. 31, no. 2, 2012, pp. 207-216.
Mueller, S. G., Weiner, M. W., Thal, L. J., Petersen, R. C., Jack, C. R., Jagust, W., et al. (2005). Ways toward an early diagnosis in Alzheimer’s disease: The Alzheimer’s disease neuroimaging initiative (ADNI). Alzheimer’s Dement., 1, 55-66.
Ho AJ, Hua X, Lee S, Leow AD, Yanovsky I, Gutman B, Dinov ID, Leporé N, Stein JL, Toga AW, Jack CR Jr, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry. Hum Brain Mapp. 2010 Apr;31(4):499-514. doi: 10.1002/hbm.20882. PMID: 19780044; PMCID: PMC2875376.
Gao, J., Jiang, Q., Zhou, B., & Chen, D. "Convolutional neural networks for computer-aided detection or diagnosis in medical image analysis: An overview." Mathematical Biosciences and Engineering, vol. 16, no. 6, 2019, pp. 6536-6561.
Park, M.; Moon, W.J.; Structural, M.R. Imaging in the Diagnosis of Alzheimer’s Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives. Korean J. Radiol. 2016, 17, 827–845
Research Imaging Institute — Mango (mangoviewer.com)
Douglas W. Scharre, MD, Preclinical,Prodronal and Dementia Sages of Alzheimer’s Disease, Practical Neurology, June 2019
Cecotti, H., & Graeser, A. "Convolutional neural network with embedded Fourier transform for E.E.G. classification." Proceedings of the 19th International Conference on Pattern Recognition, 2008, pp. 1-14.
Feng, Q., Chen, W., Zheng, P., & Yu, H. (2019). A novel Alzheimer's disease detection model with deep convolutional neural networks. Frontiers in Neuroscience, 13, 509.
Rezaei, M., Alipoor, M., &Sahraian, M. A. (2019). MRI-based radiomics for Alzheimer's disease prediction: A systematic review. Journal of Alzheimer's Disease, 72(3), 771-786
Balachandar, R., Ahmad, S., Sharmila, S., & Begum, S. (2019). Detecting Alzheimer's disease using 3D convolutional neural network with MRI images. Informatics in Medicine Unlocked, 15, 100188.
Kwon, D., Akbari, H., Da, X., Gaonkar, B., & Davatzikos, C. "Multimodal brain tumor image segmentation using GLISTR." Proceedings of the BRATS-MICCAI (2014), 2014, pp. 18-19.
Hosseini-Asl, E., Hajian-Tilaki, K., & Mahmoudi-Nezhad, G. S. (2020). Radiomics-based classification of Alzheimer's disease and mild cognitive impairment from structural MRI. Journal of Neuroscience Methods, 348, 108977.
Downloads
Published
How to Cite
Issue
Section
License
![Creative Commons License](http://i.creativecommons.org/l/by-sa/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
All papers should be submitted electronically. All submitted manuscripts must be original work that is not under submission at another journal or under consideration for publication in another form, such as a monograph or chapter of a book. Authors of submitted papers are obligated not to submit their paper for publication elsewhere until an editorial decision is rendered on their submission. Further, authors of accepted papers are prohibited from publishing the results in other publications that appear before the paper is published in the Journal unless they receive approval for doing so from the Editor-In-Chief.
IJISAE open access articles are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets the audience to give appropriate credit, provide a link to the license, and indicate if changes were made and if they remix, transform, or build upon the material, they must distribute contributions under the same license as the original.