Design and Modelling of a Glucose Optical Sensor for Diabetes Monitoring

Authors

  • Sivakumar Ramachandran Department of Electronics and Communication, Government Engineering College Wayanad, Kerala, India
  • Aiswarya Prakash Department of Electronics and Communication Engineering, College of Engineering Trivandrum, Kerala, India
  • Bejoy Abraham Department of Computer Science and Engineering, College of Engineering Muttathara, Kerala, India
  • Biju V. G. Department of Electronics and Communication Engineering, College of Engineering Munnar, Kerala, India

Keywords:

Blood glucose measurement, Diabetes monitoring, NIR sensor, Non-invasive

Abstract

The prevalence of diabetes world- wide necessitates frequent monitoring of blood glucose levels for appropriate insulin dosing and risk management. Current techniques involve invasive finger pricking with lancing devices, which can be painful and may result in infections. This study proposes a non-invasive approach using near-infrared (NIR) LED light to illuminate a glucose solution that mimics blood and the transmitted photons are further processed to obtain glucose levels. The impact of glucose concentration on NIR sensor output voltage was examined across varying concentrations, and a glucose sensor circuit was simulated using LTspice software to test efficacy across a range of concentrations. The proposed study demonstrated the feasibility of using NIR LED light and the associated sensor circuit to monitor glucose concentrations non-invasively. The findings indicated that higher glucose concentrations resulted in lower sensor output voltages. The regression analysis allowed for the development of a mathematical model to estimate glucose concentration based on the observed output voltage. This research offers a promising approach for the development of non-invasive glucose monitoring systems, which could greatly benefit individuals with diabetes by eliminating the need for frequent finger pricking and associated complications.

Downloads

Download data is not yet available.

References

J. Lynn, M. Park, C. Ogunwale, G. K. Acquaah Mensah, A tale of two diseases: Exploring mechanisms linking diabetes mellitus with alzheimer’s disease, Journal of Alzheimer’s Disease 85 (2) (2022) 485–501.

Y. Pan, M. Shao, P. Li, C. Xu, J. Nie, K. Zhang, S. Wu, D. Sui, F.-J. Xu, Polyaminoglycoside- mediated cell reprogramming system for the treat- ment of diabetes mellitus, Journal of Controlled Re- lease 343 (2022) 420–433.

P. Narkhede, S. Dhalwar, B. Karthikeyan, Nir based non-invasive blood glucose measurement, Indian Journal of science and technology 9 (41) (2016) 1–5.

W. Villena Gonzales, A. T. Mobashsher, A. Abbosh, The progress of glucose monitoring—a review of invasive to minimally and non-invasive techniques, de- vices and sensors, Sensors 19 (4) (2019) 800.

R. Hotmartua, P. W. Pangestu, H. Zakaria, Y. S. Irawan, Noninvasive blood glucose detection using near infrared sensor, in: 2015 International Conference on Electrical Engineering and Informatics (ICEEI), IEEE, 2015, pp. 687–692.

M. Shokrekhodaei, D. P. Cistola, R. C. Roberts,S. Quinones, Non-invasive glucose monitoring using optical sensor and machine learning techniques for diabetes applications, IEEE Access 9 (2021) 73029– 73045.

M. Shokrekhodaei, S. Quinones, Review of non- invasive glucose sensing techniques: optical, electrical and breath acetone, Sensors 20 (5) (2020) 1251.

V. P. Rachim, W.-Y. Chung, Wearable-band type visible-near infrared optical biosensor for non- invasive blood glucose monitoring, Sensors and Actuators B: Chemical 286 (2019) 173–180.

R. V. Kuranov, V. V. Sapozhnikova, D. S. Prough, I.Cicenaite, R. O. Esenaliev, Prediction capability of optical coherence tomography for blood glucose concentration monitoring (2007).

H. Ullah, F. Hussain, M. Ikram, Optical coherence tomography for glucose monitoring in blood, Applied Physics B 120 (2015) 355–366.

J. Shao, M. Lin, Y. Li, X. Li, J. Liu, J. Liang, H. Yao, In vivo blood glucose quantification using raman spectroscopy, PloS one 7 (10) (2012) e48127.

N. Li, H. Zang, H. Sun, X. Jiao, K. Wang, T. C.-Y. Liu, Y. Meng, A noninvasive accurate measurement of blood glucose levels with raman spectroscopy of blood in microvessels, Molecules 24 (8) (2019) 1500.

G. Purvinis, B. D. Cameron, D. M. Altrogge, Non-invasive polarimetric-based glucose monitoring: an in vivo study, Journal of diabetes science and technology 5 (2) (2011) 380–387.

D. Li, C. Xu, M. Zhang, X. Wang, K. Guo, Y. Sun, J. Gao, Z. Guo, Measuring glucose concentration in a solution based on the indices of polarimetric purity, Biomedical Optics Express 12 (4) (2021) 2447– 2459.

M. C. Cebedio, L. A. Rabioglio, I. E. Gelosi, R. A. Ribas, A. J. Uriz, J. C. Moreira, Analysis and de- sign of a microwave coplanar sensor for non-invasive blood glucose measurements, IEEE Sensors Journal 20 (18) (2020) 10572–10581.

A.Ebrahimi, J. Scott, K. Ghorbani, Microwave reflective biosensor for glucose level detection in aqueous solutions, Sensors and Actuators A: Physical 301 (2020) 111662.

R. J. Buford, E. C. Green, M. J. McClung, A microwave frequency sensor for non-invasive blood- glucose measurement, in: 2008 IEEE Sensors Applications Symposium, IEEE, 2008, pp. 4–7.

R. Sivakumar, R. S. Chandran, Non invasive abnormality detection in tissue optical phantoms using transillumination technique, in: 2013 Inter- national Mutli-Conference on Automation, Computing, Communication, Control and Compressed Sensing (iMac4s), 2013, pp. 47–51.

R. Sivakumar, N. Sujatha, A non invasive tomography system for characterization and visualization of tissue optical phantoms, International Journal of Circuits, Systems and Signal Processing 8 (2014).

M. D. Keller, S. K. Majumder, M. C. Kelley, I.M. Meszoely, F. I. Boulos, G. M. Olivares, A. Mahadevan-Jansen, Auto fluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis, Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery 42 (1) (2010) 15–23.

R. J. Nordstrom, L. Burke, J. M. Niloff, J. F. Myrtle, Identification of cervical intraepithelial neoplasia (cin) using uv-excited fluorescence and diffuse-reflectance tissue spectroscopy, Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery 29 (2) (2001) 118–127.

A.Oglat, et al., A review of blood-mimicking fluid properties using doppler ultrasound applications, Journal of Medical Ultrasound 30 (4) (2022) 251.

P. Di Ninni, F. Martelli, G. Zaccanti, The use of india ink in tissue-simulating phantoms, Optics express 18 (26) (2010) 26854–26865.

Yulia Sokolova, Deep Learning for Emotion Recognition in Human-Computer Interaction , Machine Learning Applications Conference Proceedings, Vol 3 2023.

Christopher Davies, Matthew Martinez, Catalina Fernández, Ana Flores, Anders Pedersen. Applying Recommender Systems in Educational Platforms. Kuwait Journal of Machine Learning, 2(1). Retrieved from http://kuwaitjournals.com/index.php/kjml/article/view/171

Kshirsagar, P. R., Reddy, D. H., Dhingra, M., Dhabliya, D., & Gupta, A. (2022). Detection of liver disease using machine learning approach. Paper presented at the Proceedings of 5th International Conference on Contemporary Computing and Informatics, IC3I 2022, 1824-1829. doi:10.1109/IC3I56241.2022.10073425 Retrieved from www.scopus.com

Downloads

Published

16.07.2023

How to Cite

Ramachandran, S. ., Prakash, A. ., Abraham, B. ., & V. G., B. . (2023). Design and Modelling of a Glucose Optical Sensor for Diabetes Monitoring. International Journal of Intelligent Systems and Applications in Engineering, 11(3), 570–577. Retrieved from https://ijisae.org/index.php/IJISAE/article/view/3259

Issue

Section

Research Article